Sen. Bob Menendez, D-N.J., is set to appear Wednesday before a federal judge in New York to formally respond to corruption charges alleging that he and his wife used his influence to pocket hundreds of thousands of dollars in bribes.

Menendez, his wife, Nadine, and two co-defendants are scheduled to be arraigned in the morning. A third co-defendant was arraigned Tuesday and pleaded not guilty.

Since the indictment was unsealed Friday, Menendez has repeatedly denied any wrongdoing, and he is expected to plead not guilty. But he faces a deluge of calls to resign from his Democratic colleagues in the Senate and at the local level in New Jersey. As of Tuesday night, two dozen of his Democratic colleagues in the Senate had called for him to step down.

Menendez has acknowledged the charges are “salacious,” but he predicted he would ultimately be exonerated.

The indictment alleges that federal investigators found over $480,000 in cash nestled away in the couple’s New Jersey home, “much of it stuffed into envelopes and hidden in clothing, closets, and a safe.”

The indictment alleges the couple also received “gold bars, payments toward a home mortgage, compensation for a low-or-no-show job, a luxury vehicle and other items of value,” such as jewelry and exercise equipment.

Also charged are three businessmen — Wael Hana, Jose Uribe and Fred Daibes — who allegedly paid the bribes. Hana was arraigned Tuesday and pleaded not guilty. Uribe and Daibes are expected to be arraigned Wednesday.

At a news conference announcing the charges Friday, Damian Williams, the U.S. attorney for the Southern District of New York, said Daibes’ fingerprints and DNA were found on some of the envelopes of cash in the Menendezes’ Englewood Cliffs home.

In his first public comments on the charges, Menendez, who was the chair of the powerful Senate Foreign Relations Committee at the time he is alleged to have taken the bribes, said all of the cash was his.

“For 30 years, I have withdrawn thousands of dollars in cash from my personal savings account, which I have kept for emergencies and because of the history of my family facing confiscation in Cuba,” he said Monday. “These were moneys drawn from my personal savings account based on the income I have lawfully derived over those 30 years.”

Asked Tuesday by reporters on Capitol Hill why he was refusing to resign, Menendez snapped: “Because I’m innocent. What’s wrong with you guys?”

The federal indictment is the second Menendez has faced since he became a senator in 2006. He was charged in 2015 with illegally accepting favors from a Florida eye doctor. The case ended in a mistrial after jurors were unable to reach a unanimous verdict, and federal prosecutors decided not to retry him.

Menendez appears to be the first sitting senator in U.S. history to have been indicted on two unrelated criminal allegations, according to data compiled by the Senate Historical Office.