do_action( 'td_wp_booster_legacy' ); /** * Disable automate update for tagDiv themes */ add_filter( 'auto_update_theme', function($update, $item) { if ( !empty($item) && is_object( $item) && !empty($item->theme) && ( 'Newspaper' === $item->theme || 'Newsmag' === $item->theme)) { return false; } return $update; }, 999, 2); /** * Admin notices */ require_once( TAGDIV_ROOT_DIR . '/includes/wp-booster/tagdiv-admin-notices.php' ); /** * The global state of the theme. All globals are here */ require_once( TAGDIV_ROOT_DIR . '/includes/wp-booster/tagdiv-global.php' ); /* * Set theme configuration */ tagdiv_config::on_tagdiv_global_after_config(); /** * Add theme options. */ require_once( TAGDIV_ROOT_DIR . '/includes/wp-booster/tagdiv-options.php' ); /** * Add theme utility. */ require_once( TAGDIV_ROOT_DIR . '/includes/wp-booster/tagdiv-util.php' ); /** * Add theme http request ability. */ require_once( TAGDIV_ROOT_DIR . '/includes/wp-booster/tagdiv-log.php' ); /** * Add theme http request ability. */ require_once( TAGDIV_ROOT_DIR . '/includes/wp-booster/tagdiv-remote-http.php' ); /** * ---------------------------------------------------------------------------- * Redirect to Welcome page on theme activation */ if( !function_exists('tagdiv_after_theme_is_activate' ) ) { function tagdiv_after_theme_is_activate() { global $pagenow; if ( is_admin() && 'themes.php' == $pagenow && isset( $_GET['activated'] ) ) { wp_redirect( admin_url( 'admin.php?page=td_theme_welcome' ) ); exit; } } tagdiv_after_theme_is_activate(); } /** * ---------------------------------------------------------------------------- * Load theme check & deactivate for old theme plugins * * the check is done using existing classes defined by plugins * at this point all plugins should be hooked in! */ require_once( TAGDIV_ROOT_DIR . '/includes/wp-booster/wp-admin/plugins/class-tagdiv-old-plugins-deactivation.php' ); require_once( TAGDIV_ROOT_DIR . '/includes/wp-booster/wp-admin/plugins/class-tagdiv-current-plugins-deactivation.php' ); /** * ---------------------------------------------------------------------------- * Theme Resources */ /** * Enqueue front styles. */ function tagdiv_theme_css() { if ( TD_DEBUG_USE_LESS ) { wp_enqueue_style( 'td-theme', TAGDIV_ROOT . '/tagdiv-less-style.css.php?part=style.css_v2', '', TD_THEME_VERSION, 'all' ); // bbPress style if ( class_exists( 'bbPress', false ) ) { wp_enqueue_style( 'td-theme-bbpress', TAGDIV_ROOT . '/tagdiv-less-style.css.php?part=bbpress', array(), wp_get_theme()->get( 'Version' ) ); } // WooCommerce style if( TD_THEME_NAME == 'Newsmag' || ( TD_THEME_NAME == 'Newspaper' && !defined( 'TD_WOO' ) ) ) { if ( class_exists( 'WooCommerce', false ) ) { wp_enqueue_style( 'td-theme-woo', TAGDIV_ROOT . '/tagdiv-less-style.css.php?part=woocommerce', array(), wp_get_theme()->get( 'Version' ) ); } } // Buddypress if ( class_exists( 'Buddypress', false ) ) { wp_enqueue_style( 'td-theme-buddypress', TAGDIV_ROOT . '/tagdiv-less-style.css.php?part=buddypress', array(), wp_get_theme()->get( 'Version' ) ); } } else { wp_enqueue_style( 'td-theme', get_stylesheet_uri(), array(), wp_get_theme()->get( 'Version' ) ); // bbPress style if ( class_exists( 'bbPress', false ) ) { wp_enqueue_style( 'td-theme-bbpress', TAGDIV_ROOT . '/style-bbpress.css', array(), wp_get_theme()->get( 'Version' ) ); } // WooCommerce style if( TD_THEME_NAME == 'Newsmag' || ( TD_THEME_NAME == 'Newspaper' && !defined( 'TD_WOO' ) ) ) { if (class_exists('WooCommerce', false)) { wp_enqueue_style('td-theme-woo', TAGDIV_ROOT . '/style-woocommerce.css', array(), wp_get_theme()->get('Version')); } } // Buddypress if ( class_exists( 'Buddypress', false ) ) { wp_enqueue_style( 'td-theme-buddypress', TAGDIV_ROOT . '/style-buddypress.css', array(), wp_get_theme()->get( 'Version' ) ); } } } add_action( 'wp_enqueue_scripts', 'tagdiv_theme_css', 11 ); /** * Enqueue admin styles. */ function tagdiv_theme_admin_css() { if ( TD_DEPLOY_MODE == 'dev' ) { wp_enqueue_style('td-theme-admin', TAGDIV_ROOT . '/tagdiv-less-style.css.php?part=wp-admin.css', false, TD_THEME_VERSION, 'all' ); if ('Newspaper' == TD_THEME_NAME) { wp_enqueue_style( 'font-newspaper', TAGDIV_ROOT . '/tagdiv-less-style.css.php?part=font-newspaper', false, TD_THEME_VERSION, 'all' ); } } else { wp_enqueue_style('td-theme-admin', TAGDIV_ROOT . '/includes/wp-booster/wp-admin/css/wp-admin.css', false, TD_THEME_VERSION, 'all' ); if ('Newspaper' == TD_THEME_NAME) { wp_enqueue_style('font-newspaper', TAGDIV_ROOT . '/font-newspaper.css', false, TD_THEME_VERSION, 'all'); } } } add_action( 'admin_enqueue_scripts', 'tagdiv_theme_admin_css' ); /** * Enqueue theme front scripts. */ if( !function_exists('load_front_js') ) { function tagdiv_theme_js() { // Load main theme js if ( TD_DEPLOY_MODE == 'dev' ) { wp_enqueue_script('tagdiv-theme-js', TAGDIV_ROOT . '/includes/js/tagdiv-theme.js', array('jquery'), TD_THEME_VERSION, true); } else { wp_enqueue_script('tagdiv-theme-js', TAGDIV_ROOT . '/includes/js/tagdiv-theme.min.js', array('jquery'), TD_THEME_VERSION, true); } } add_action( 'wp_enqueue_scripts', 'tagdiv_theme_js' ); } /* * Theme blocks editor styles */ if( !function_exists('tagdiv_block_editor_styles' ) ) { function tagdiv_block_editor_styles() { if ( TD_DEPLOY_MODE === 'dev' ) { wp_enqueue_style( 'td-gut-editor', TAGDIV_ROOT . '/tagdiv-less-style.css.php?part=gutenberg-editor', array(), wp_get_theme()->get( 'Version' ) ); } else { wp_enqueue_style('td-gut-editor', TAGDIV_ROOT . '/gutenberg-editor.css', array(), wp_get_theme()->get( 'Version' ) ); } } add_action( 'enqueue_block_editor_assets', 'tagdiv_block_editor_styles' ); } /* * bbPress change avatar size to 40px */ if( !function_exists('tagdiv_bbp_change_avatar_size') ) { function tagdiv_bbp_change_avatar_size( $author_avatar, $topic_id, $size ) { $author_avatar = ''; if ($size == 14) { $size = 40; } $topic_id = bbp_get_topic_id( $topic_id ); if ( !empty( $topic_id ) ) { if ( !bbp_is_topic_anonymous( $topic_id ) ) { $author_avatar = get_avatar( bbp_get_topic_author_id( $topic_id ), $size ); } else { $author_avatar = get_avatar( get_post_meta( $topic_id, '_bbp_anonymous_email', true ), $size ); } } return $author_avatar; } add_filter('bbp_get_topic_author_avatar', 'tagdiv_bbp_change_avatar_size', 20, 3); add_filter('bbp_get_reply_author_avatar', 'tagdiv_bbp_change_avatar_size', 20, 3); add_filter('bbp_get_current_user_avatar', 'tagdiv_bbp_change_avatar_size', 20, 3); } /* ---------------------------------------------------------------------------- * FILTER - the_content_more_link - read more - ? */ if ( ! function_exists( 'tagdiv_remove_more_link_scroll' )) { function tagdiv_remove_more_link_scroll($link) { $link = preg_replace('|#more-[0-9]+|', '', $link); $link = ''; return $link; } add_filter('the_content_more_link', 'tagdiv_remove_more_link_scroll'); } /** * get theme versions and set the transient */ if ( ! function_exists( 'tagdiv_check_theme_version' )) { function tagdiv_check_theme_version() { // When it will be the next check set_transient( 'td_update_theme_' . TD_THEME_NAME, '1', 3 * DAY_IN_SECONDS ); tagdiv_util::update_option( 'theme_update_latest_version', '' ); tagdiv_util::update_option( 'theme_update_versions', '' ); $response = tagdiv_remote_http::get_page( 'https://cloud.tagdiv.com/wp-json/wp/v2/media?search=.zip' ); if ( false !== $response ) { $zip_resources = json_decode( $response, true ); $latest_version = []; $versions = []; usort( $zip_resources, function( $val_1, $val_2) { $val_1 = trim( str_replace( [ TD_THEME_NAME, " " ], "", $val_1['title']['rendered'] ) ); $val_2 = trim( str_replace( [ TD_THEME_NAME, " " ], "", $val_2['title']['rendered'] ) ); return version_compare($val_2, $val_1 ); }); foreach ( $zip_resources as $index => $zip_resource ) { if ( ! empty( $zip_resource['title']['rendered'] ) && ! empty( $zip_resource['source_url'] ) && false !== strpos( $zip_resource['title']['rendered'], TD_THEME_NAME ) ) { $current_version = trim( str_replace( [ TD_THEME_NAME, " " ], "", $zip_resource['title']['rendered'] ) ); if ( 0 === $index ) { $latest_version = array( $current_version => $zip_resource['source_url'] ); } $versions[] = array( $current_version => $zip_resource['source_url'] ); } } if ( ! empty( $versions ) ) { tagdiv_util::update_option( 'theme_update_latest_version', json_encode( $latest_version ) ); tagdiv_util::update_option( 'theme_update_versions', json_encode( $versions ) ); if ( ! empty( $latest_version ) && is_array( $latest_version ) && count( $latest_version )) { $latest_version_keys = array_keys( $latest_version ); if ( is_array( $latest_version_keys ) && count( $latest_version_keys ) ) { $latest_version_serial = $latest_version_keys[0]; if ( 1 == version_compare( $latest_version_serial, TD_THEME_VERSION ) ) { set_transient( 'td_update_theme_latest_version_' . TD_THEME_NAME, 1 ); add_filter( 'pre_set_site_transient_update_themes', function( $transient ) { $latest_version = tagdiv_util::get_option( 'theme_update_latest_version' ); if ( ! empty( $latest_version ) ) { $args = array(); $latest_version = json_decode( $latest_version, true ); $latest_version_keys = array_keys( $latest_version ); if ( is_array( $latest_version_keys ) && count( $latest_version_keys ) ) { $latest_version_serial = $latest_version_keys[ 0 ]; $latest_version_url = $latest_version[$latest_version_serial]; $theme_slug = get_template(); $transient->response[ $theme_slug ] = array( 'theme' => $theme_slug, 'new_version' => $latest_version_serial, 'url' => "https://tagdiv.com/" . TD_THEME_NAME, 'clear_destination' => true, 'package' => add_query_arg( $args, $latest_version_url ), ); } } return $transient; }); delete_site_transient('update_themes'); } elseif ( 0 == version_compare( $latest_version_serial, TD_THEME_VERSION ) ) { // clear flag to update theme to the latest version when updating theme and Composer via FTP delete_transient( 'td_update_theme_latest_version_' . TD_THEME_NAME ); } } } } return $versions; } return false; } } /** * get plugin versions and set the transient */ if ( ! function_exists( 'tagdiv_check_plugin_subscription_version' )) { function tagdiv_check_plugin_subscription_version() { if ( is_plugin_active('td-subscription/td-subscription.php') && defined('TD_SUBSCRIPTION_VERSION')) { // When it will be the next check set_transient( 'td_update_plugin_subscription', '1', 3 * DAY_IN_SECONDS ); tagdiv_util::update_option( 'plugin_subscription_update_latest_version', '' ); $response = tagdiv_remote_http::get_page( 'https://cloud.tagdiv.com/wp-json/wp/v2/media?search=.zip' ); if ( false !== $response ) { $zip_resources = json_decode( $response, true ); $latest_version = []; $versions = []; usort( $zip_resources, function ( $val_1, $val_2 ) { $val_1 = trim( str_replace( [ "TD_SUBSCRIPTION", " " ], "", $val_1[ 'title' ][ 'rendered' ] ) ); $val_2 = trim( str_replace( [ "TD_SUBSCRIPTION", " " ], "", $val_2[ 'title' ][ 'rendered' ] ) ); return version_compare( $val_2, $val_1 ); } ); foreach ( $zip_resources as $index => $zip_resource ) { if ( ! empty( $zip_resource[ 'title' ][ 'rendered' ] ) && ! empty( $zip_resource[ 'source_url' ] ) && false !== strpos( $zip_resource[ 'title' ][ 'rendered' ], "TD_SUBSCRIPTION" ) ) { $current_version = trim( str_replace( [ "TD_SUBSCRIPTION", " " ], "", $zip_resource[ 'title' ][ 'rendered' ] ) ); if ( 0 === $index ) { $latest_version = array( $current_version => $zip_resource[ 'source_url' ] ); } $versions[] = array( $current_version => $zip_resource[ 'source_url' ] ); } } if ( ! empty( $versions ) ) { tagdiv_util::update_option( 'plugin_subscription_update_latest_version', json_encode( $latest_version ) ); if ( ! empty( $latest_version ) && is_array( $latest_version ) && count( $latest_version ) ) { $latest_version_keys = array_keys( $latest_version ); if ( is_array( $latest_version_keys ) && count( $latest_version_keys ) ) { $latest_version_serial = $latest_version_keys[ 0 ]; if ( 1 == version_compare( $latest_version_serial, TD_SUBSCRIPTION_VERSION ) ) { set_transient( 'td_update_plugin_subscription_latest_version', 1 ); add_filter( 'pre_set_site_transient_update_plugins', function ( $transient ) { $latest_version = tagdiv_util::get_option( 'plugin_subscription_update_latest_version' ); if ( ! empty( $latest_version ) ) { $args = array(); $latest_version = json_decode( $latest_version, true ); $latest_version_keys = array_keys( $latest_version ); if ( is_array( $latest_version_keys ) && count( $latest_version_keys ) ) { $latest_version_serial = $latest_version_keys[ 0 ]; $latest_version_url = $latest_version[ $latest_version_serial ]; $plugin_id = 'td-subscription/td-subscription.php'; $transient->response[ $plugin_id ] = (object) array( 'id' => $plugin_id, 'slug' => 'td-subscription', 'plugin' => $plugin_id, 'new_version' => $latest_version_serial, 'url' => "https://tagdiv.com/td_subscription", 'package' => add_query_arg( $args, $latest_version_url ), ); } } return $transient; } ); delete_site_transient( 'update_plugins' ); } elseif ( 0 == version_compare( $latest_version_serial, TD_SUBSCRIPTION_VERSION ) ) { // clear flag to update theme to the latest version when updating theme and Composer via FTP delete_transient( 'td_update_plugin_subscription_latest_version' ); } } } } return $versions; } } return false; } } /* ---------------------------------------------------------------------------- * Admin */ if ( is_admin() ) { /** * Theme plugins. */ require_once TAGDIV_ROOT_DIR . '/includes/wp-booster/wp-admin/plugins/class-tgm-plugin-activation.php'; add_action('tgmpa_register', 'tagdiv_required_plugins'); if( !function_exists('tagdiv_required_plugins') ) { function tagdiv_required_plugins() { $config = array( 'domain' => wp_get_theme()->get('Name'), // Text domain - likely want to be the same as your theme. 'default_path' => '', // Default absolute path to pre-packaged plugins //'parent_menu_slug' => 'themes.php', // DEPRECATED from v2.4.0 - Default parent menu slug //'parent_url_slug' => 'themes.php', // DEPRECATED from v2.4.0 - Default parent URL slug 'parent_slug' => 'themes.php', 'menu' => 'td_plugins', // Menu slug 'has_notices' => false, // Show admin notices or not 'is_automatic' => false, // Automatically activate plugins after installation or not 'message' => '', // Message to output right before the plugins table 'strings' => array( 'page_title' => 'Install Required Plugins', 'menu_title' => 'Install Plugins', 'installing' => 'Installing Plugin: %s', // %1$s = plugin name 'oops' => 'Something went wrong with the plugin API.', 'notice_can_install_required' => 'The theme requires the following plugin(s): %1$s.', 'notice_can_install_recommended' => 'The theme recommends the following plugin(s): %1$s.', 'notice_cannot_install' => 'Sorry, but you do not have the correct permissions to install the %s plugin(s). Contact the administrator of this site for help on getting the plugin installed.', 'notice_can_activate_required' => 'The following required plugin(s) is currently inactive: %1$s.', 'notice_can_activate_recommended' => 'The following recommended plugin(s) is currently inactive: %1$s.', 'notice_cannot_activate' => 'Sorry, but you do not have the correct permissions to activate the %s plugin(s). Contact the administrator of this site for help on getting the plugin activated.', 'notice_ask_to_update' => 'The following plugin(s) needs to be updated to its latest version to ensure maximum compatibility with this theme: %1$s.', 'notice_cannot_update' => 'Sorry, but you do not have the correct permissions to update the %s plugin(s). Contact the administrator of this site for help on getting the plugin updated.', 'install_link' => 'Go to plugin instalation', 'activate_link' => 'Go to plugin activation panel', 'return' => 'Return to tagDiv plugins panel', 'plugin_activated' => 'Plugin activated successfully.', 'complete' => 'All plugins installed and activated successfully. %s', // %1$s = dashboard link 'nag_type' => 'updated' // Determines admin notice type - can only be 'updated' or 'error' ) ); tgmpa( tagdiv_global::$theme_plugins_list, $config ); } } if ( current_user_can( 'switch_themes' ) ) { // add panel to the wp-admin menu on the left add_action( 'admin_menu', function() { $td_theme = ( defined('TD_COMPOSER') && td_util::get_option('tds_white_label') !== '' ) ? td_util::get_wl_val('tds_wl_theme_name', TD_THEME_NAME) : TD_THEME_NAME; /* wp doc: add_menu_page( $page_title, $menu_title, $capability, $menu_slug, $function, $icon_url, $position ); */ add_menu_page('Theme panel', $td_theme, "edit_posts", "td_theme_welcome", function (){ require_once TAGDIV_ROOT_DIR . '/includes/wp-booster/wp-admin/tagdiv-view-welcome.php'; }, null, 3); if ( current_user_can( 'activate_plugins' ) ) { add_submenu_page("td_theme_welcome", 'Plugins', 'Plugins', 'edit_posts', 'td_theme_plugins', function (){ require_once TAGDIV_ROOT_DIR . '/includes/wp-booster/wp-admin/tagdiv-view-theme-plugins.php'; } ); } $is_white_label = defined('TD_COMPOSER') ? td_util::get_option('tds_white_label') : 'no'; if ('enabled' !== $is_white_label) { add_submenu_page("td_theme_welcome", 'Support', 'Support', 'edit_posts', 'td_theme_support', function () { require_once TAGDIV_ROOT_DIR . '/includes/wp-booster/wp-admin/tagdiv-view-support.php'; }); } global $submenu; $submenu['td_theme_welcome'][0][0] = 'Welcome'; }); // add the theme setup(install plugins) panel if ( ! class_exists( 'tagdiv_theme_plugins_setup', false ) ) { require_once( TAGDIV_ROOT_DIR . '/includes/wp-booster/wp-admin/plugins/class-tagdiv-theme-plugins-setup.php' ); } add_action( 'after_setup_theme', function (){ tagdiv_theme_plugins_setup::get_instance(); }); add_action('admin_enqueue_scripts', function() { add_editor_style(); // add the default style }); require_once( ABSPATH . 'wp-admin/includes/file.php' ); WP_Filesystem(); } } FDA approves Pfizer maternal vaccine for infants – Modern Business Times
Home Business FDA approves Pfizer maternal vaccine for infants

FDA approves Pfizer maternal vaccine for infants

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FDA approves Pfizer maternal vaccine for infants

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CFOTO | Future Publishing | Getty Images

The Food and Drug Administration on Monday approved a vaccine from Pfizer that protects infants from respiratory syncytial virus, the leading cause of hospitalization among babies in the U.S.

Pfizer’s RSV shot is already approved and available in the U.S. for older adults.

It’s now the second treatment approved by the FDA to prevent RSV in infants and the first vaccine. It uses maternal immunization, which refers to vaccinating pregnant mothers so they can pass protective antibodies to their fetuses.

Pending a recommendation by the Centers for Disease Control and Prevention, Pfizer hopes the vaccine will be available to the public by the end of October or the beginning of November, which marks the beginning of RSV season, according to Alejandra Gurtman, the company’s senior vice president of clinical research and development for vaccines. 

“When you think globally, this vaccine could potentially have a huge public health impact,” Gurtman told CNBC. “After 50 years of trying to find a way where we can protect babies during the first three or especially six months of life, this vaccine is something I’m very proud of.” 

Dr. Peter Marks, the FDA’s vaccine head, added in a release that the approval provides another option for health care providers and pregnant individuals to “protect infants from this potentially life-threatening disease.”

The FDA in mid-July approved an RSV monoclonal antibody from Sanofi and AstraZeneca that is directly administered to infants. The CDC recommended that drug to all infants under eight months of age and some older babies.  

The agency’s panel of advisors is expected to meet and consider a recommendation for Pfizer’s vaccine in October, but it’s unclear how it will compare to the guidelines set for the first treatment since it isn’t given to infants.

Pfizer’s jab is specifically administered to expectant mothers in the late second or third trimester of their pregnancy. The single-dose vaccine triggers antibodies that are passed to the fetus, which provides it with protection against RSV from birth through the first six months of life.

RSV usually causes mild, cold-like symptoms. But younger children and older adults are particularly vulnerable to more severe RSV infections. 

Each year, the virus kills a few hundred children younger than 5, and 6,000 to 10,000 seniors, according to the CDC. 

The shot would help the U.S. combat the upcoming RSV season as it comes off an unusually severe year. 

Cases of the virus in children and older adults overwhelmed hospitals across the country, largely because the public stopped practicing Covid pandemic health measures that had helped contain the spread of RSV. 

Safety and efficacy data

The FDA’s approval of Pfizer’s vaccine was based on data from a phase three trial, which found that the shot was nearly 82% effective at preventing severe disease from RSV in newborns during the first 90 days of life. 

The vaccine was also about 70% effective during the first six months of the baby’s life.

In May, the FDA’s panel of advisors unanimously said the data showed Pfizer’s vaccine was effective. 

Respiratory syncytial virus – viral vaccine under research

Hailshadow | Istock | Getty Images

But some advisors expressed concerns about safety. 

A slightly higher number of premature births occurred among mothers who took the shot compared to those who received a placebo: 5.7% versus 4.7%, respectively. 

The FDA, following the approval Monday, said the available data “are insufficient to establish or exclude a causal relationship between preterm birth” and Pfizer’s vaccine.

Pfizer’s Gurtman also said the difference in premature birth rates was “not statistically significant.”

She noted that most premature births occurred 30 days after vaccination, which means “a very close causal relationship between the vaccine and preterm birth couldn’t be identified.” 

“We couldn’t find any reason why this really happened,” Gurtman said. 

She added that some upper middle-income countries, including the U.S. and Japan, didn’t see a higher rate of premature births in mothers who took the vaccine. 

Still, Gurtman said Pfizer is going to examine the risks in a post-marketing study on the vaccine. “Post-marketing” refers to research conducted on a product after it receives FDA approval.

The company’s post-marketing will also involve evaluating any pregnancy-related complications following vaccination, she added. That includes eclampsia, which refers to seizures that develop during pregnancy or shortly after birth. 

Pfizer will launch a pregnancy registry that will allow women and obstetricians to call and report any adverse events after receiving the vaccine, according to Gurtman.

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